When x360ce starts for the first time, it will prompt you that xinput1_3.dll is missing. Allow the program to . It will also ask if you want to search the internet for pre-made controller settings. Say Yes to this; it can save you a lot of time by automatically mapping buttons for popular controllers.
The development team introduced several critical fixes in the 4.10.0.0 build to resolve structural bugs from older iterations: x360ce 41000 link