set by major zoo associations regarding the breeding of rare phenotypes.
Scientists used whole genome sequencing to study the genetic cause of his albinism. They successfully identified the causal genetic variant: a non-synonymous single nucleotide variant located in a transmembrane region of the SLC45A2 gene, a transporter known to be involved in oculocutaneous albinism type 4 (OCA4) in humans. Experimental evidence showed that this amino acid replacement alters the membrane spanning capability of this transmembrane region. set by major zoo associations regarding the breeding
Removing animals with a probability of carrying the albinism allele would result in loss of founder alleles considered particularly valuable to the population's genetic diversity. This creates a fundamental conservation dilemma: eliminating carriers of a deleterious allele may preserve population health but at the cost of reducing overall genetic diversity, while retaining carriers perpetuates the hereditary disorder within the population. set by major zoo associations regarding the breeding